CS Seminar
Friday, February 6th
11am-12pm, ST2 Room 430


GENOMIC SIGNAL ANALYSIS OF LARGE SCALE FEATURES OF CHROMOSOMES AND CONCATENATED REORIENTED CODING REGIONS

Prof. Paul Dan Cristea
Biomedical Engineering Center,
"Politehnica" University of Bucharest,
Spl. Independentei 313, 060042 Bucharest, Romania
pcristea@dsp.pub.ro


Abstract:

The almost complete sequencing of several genomes, including the human genome, as well as the public access to this vast amount of information, offer the opportunity to data mine and explore in depth this unique empiric data depository. For storage purposes, genomic information at nucleotide level is represented as symbolic sequences. For analysis purposes, the conversion of genomic sequences into digital signals opens the possibility to use powerful signal processing methods for handling genomic information. The study of complex genomic signals reveals large scale features of chromosomes, maintained over distances of 106 - 108 base pairs. By reorienting all coding regions of prokaryote genomes in the same direction, it can be shown that nuclear genomic material in both linear and circular chromosomes presents the same regularities pointing towards the hypothesis of a regular ancestral structure from which the current chromosome structures have evolved. This property is not shared by non-nuclear genomic material e.g., plasmids.

Bio:

Paul Cristea graduated from the Faculty of Electronics and Telecommunications (UPB - University "Politehnica" of Bucharest) in 1962, the Faculty of Physics (University of Bucharest) in 1969, and obtained the Ph.D. in Technical Physics (UPB) in 1970. His research and teaching activities have been in the fields of Genomic Signals, Digital Signal and Image Processing, Connectionist and Evolutionary Systems, Intelligent e-Learning Environments, Computerized Medical Equipment and Special Electrical Batteries. He is the author or co-author of more then 125 published papers, 13 patents, and contributed to more than 20 books in these fields. Currently, he is professor and coordinator of the Electrical Engineering and Computers Division of the Faculty of Engineering of UPB, general manager of the Bio-Medical Engineering Center of UPB and director of the Romanian Bioinformatics Society.

Contact Person:
Prof. George Tecuci, tecuci@gmu.edu