Author: Jake Yeston

Author: Sacha Vignieri

Author: John F. Foley

Author: Julia Fahrenkamp-Uppenbrink

Author: Pamela J. Hines

Author: Paula A. Kiberstis

Author: Guy Riddihough

Author: Jelena Stajic

Author: Sacha Vignieri

Author: Ian S. Osborne

Author: Phil Szuromi

Author: Brent Grocholski

Author: Laura Schuhmacher

Author: Paula A. Kiberstis

Author: L. Bryan Ray

Colloidal particles with well-controlled shapes and interactions are an ideal experimental system for exploring how matter organizes itself. Like atoms and molecules, these particles form bulk phases such as liquids and crystals. But they are more than just crude analogs of atoms; they are a form of matter in their own right, with complex and interesting collective behavior not seen at the atomic scale. Their behavior is affected by geometrical or topological constraints, such as curved surfaces or the shapes of the particles. Because the interactions between the particles are often short-ranged, we can understand the effects of these constraints using geometrical concepts such as packing. The geometrical viewpoint gives us a window into how entropy affects not only the structure of matter, but also the dynamics of how it forms. Author: Vinothan N. Manoharan

Super-resolution fluorescence microscopy is distinct among nanoscale imaging tools in its ability to image protein dynamics in living cells. Structured illumination microscopy (SIM) stands out in this regard because of its high speed and low illumination intensities, but typically offers only a twofold resolution gain. We extended the resolution of live-cell SIM through two approaches: ultrahigh numerical aperture SIM at 84-nanometer lateral resolution for more than 100 multicolor frames, and nonlinear SIM with patterned activation at 45- to 62-nanometer resolution for approximately 20 to 40 frames. We applied these approaches to image dynamics near the plasma membrane of spatially resolved assemblies of clathrin and caveolin, Rab5a in early endosomes, and α-actinin, often in relationship to cortical actin. In addition, we examined mitochondria, actin, and the Golgi apparatus dynamics in three dimensions. Authors: Dong Li, Lin Shao, Bi-Chang Chen, Xi Zhang, Mingshu Zhang, Brian Moses, Daniel E. Milkie, Jordan R. Beach, John A. Hammer, Mithun Pasham, Tomas Kirchhausen, Michelle A. Baird, Michael W. Davidson, Pingyong Xu, Eric Betzig

Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams. Author:

Scattering among electrons generates a distinct contribution to electrical resistivity that follows a quadratic temperature (T) dependence. In strongly correlated electron systems, the prefactor A of this T2 resistivity scales with the magnitude of the electronic specific heat, γ. Here we show that one can change the magnitude of A by four orders of magnitude in metallic strontium titanate (SrTiO3) by tuning the concentration of the carriers and, consequently, the Fermi energy. The T2 behavior persists in the single-band dilute limit despite the absence of two known mechanisms for T2 behavior: distinct electron reservoirs and Umklapp processes. The results highlight the absence of a microscopic theory for momentum decay through electron-electron scattering in various Fermi liquids. Authors: Xiao Lin, Benoît Fauqué, Kamran Behnia

A magnetic domain boundary on the surface of a three-dimensional topological insulator is predicted to host a chiral edge state, but direct demonstration is challenging. We used a scanning superconducting quantum interference device to show that current in a magnetized topological insulator heterostructure (EuS/Bi2Se3) flows at the edge when the Fermi level is gate-tuned to the surface band gap. We further induced micrometer-scale magnetic structures on the heterostructure and detected a chiral edge current at the magnetic domain boundary. The chirality of the current was determined by magnetization of the surrounding domain, and its magnitude by the local chemical potential rather than the applied current. Such magnetic structures provide a platform for detecting topological magnetoelectric effects and may enable progress in quantum information processing and spintronics. Authors: Y. H. Wang, J. R. Kirtley, F. Katmis, P. Jarillo-Herrero, J. S. Moodera, K. A. Moler