Journal Articles

  • Molecular Dynamics Simulations of Scorpion Toxin Recognition by the Ca2+-Activated Potassium Channel KCa3.1
    [Oct 2013]

    Rong Chen, Shin-Ho Chung. The Ca2+-activated channel of intermediate-conductance (KCa3.1) is a target for antisickling and immunosuppressant agents. Many small peptides isolated from animal venoms inh....
    Categories: Journal Articles
  • The Structural Basis of Cholesterol Accessibility in Membranes
    [Oct 2013]

    Brett N. Olsen, Agata A. Bielska, Tiffany Lee, Michael D. Daily, Douglas F. Covey, Paul H. Schlesinger, Nathan A. Baker, Daniel S. Ory. Although the majority of free cellular cholesterol is present in the plasma membrane, cholesterol homeostasis is principally regulated through sterol-sensing proteins that reside in the cholestero....
    Categories: Journal Articles
  • Effects of Detergent β-Octylglucoside and Phosphate Salt Solutions on Phase Behavior of Monoolein Mesophases
    [Oct 2013]

    Daria S. Khvostichenko, Johnathan J.D. Ng, Sarah L. Perry, Monisha Menon, Paul J.A. Kenis. Using small-angle x-ray scattering (SAXS), we investigated the phase behavior of mesophases of monoolein (MO) mixed with additives commonly used for the crystallization of membrane proteins from l....
    Categories: Journal Articles
  • Cohesiveness tunes assembly and morphology of FG nucleoporin domain meshworks – Implications for nuclear pore permeability
    [Oct 2013]

    Nico B. Eisele, Aksana A. Labokha, Steffen Frey, Dirk Görlich, Ralf P. Richter. Nuclear pore complexes control the exchange of macromolecules between the cytoplasm and the nucleus. A selective permeability barrier that arises from a supramolecular assembly of intrinsically un....
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  • Nonlinear Cross-Bridge Elasticity and Post-Power-Stroke Events in Fast Skeletal Muscle Actomyosin
    [Oct 2013]

    Malin Persson, Elina Bengtsson, Lasse ten Siethoff, Alf Månsson. Generation of force and movement by actomyosin cross-bridges is the molecular basis of muscle contraction, but generally accepted ideas about cross-bridge properties have recently been questioned.....
    Categories: Journal Articles
  • Probing the Flexibility of Tropomyosin and Its Binding to Filamentous Actin Using Molecular Dynamics Simulations
    [Oct 2013]

    Wenjun Zheng, Bipasha Barua, Sarah E. Hitchcock-DeGregori. Tropomyosin (Tm) is a coiled-coil protein that binds to filamentous actin (F-actin) and regulates its interactions with actin-binding proteins like myosin by moving between three positions on F-ac....
    Categories: Journal Articles
  • Structural Transitions and Energy Landscape for Cowpea Chlorotic Mottle Virus Capsid Mechanics from Nanomanipulation in Vitro and in Silico
    [Oct 2013]

    Olga Kononova, Joost Snijder, Melanie Brasch, Jeroen Cornelissen, Ruxandra I. Dima, Kenneth A. Marx, Gijs J.L. Wuite, Wouter H. Roos, Valeri Barsegov. Physical properties of capsids of plant and animal viruses are important factors in capsid self-assembly, survival of viruses in the extracellular environment, and their cell infectivity. Combined....
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  • Temperature Dependence of the DNA Double Helix at the Nanoscale: Structure, Elasticity, and Fluctuations
    [Oct 2013]

    Sam Meyer, Daniel Jost, Nikos Theodorakopoulos, Michel Peyrard, Richard Lavery, Ralf Everaers. Biological organisms exist over a broad temperature range of −15°C to +120°C, where many molecular processes involving DNA depend on the nanoscale properties of the double helix. Here, we present ....
    Categories: Journal Articles
  • A Bacterial Swimmer with Two Alternating Speeds of Propagation
    [Oct 2013]

    Matthias Theves, Johannes Taktikos, Vasily Zaburdaev, Holger Stark, Carsten Beta. We recorded large data sets of swimming trajectories of the soil bacterium Pseudomonas putida. Like other prokaryotic swimmers, P. putida exhibits a motion pattern dominated by persi....
    Categories: Journal Articles
  • Sensitivity and Robustness in Covalent Modification Cycles with a Bifunctional Converter Enzyme
    [Oct 2013]

    Ronny Straube. Regulation by covalent modification is a common mechanism to transmit signals in biological systems. The modifying reactions are catalyzed either by two distinct converter enzymes or by a single b....
    Categories: Journal Articles
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