Proceedings of the Natural Academy of Sciences

Proceedings of the National Academy of Sciences RSS feed -- current issue
  • A receptor-like kinase mediates fungal resistance [Plant Biology]
    [Jul 2015]

    Northern corn leaf blight (NCLB) caused by the hemibiotrophic fungus Exserohilum turcicum is an important foliar disease of maize that is mainly controlled by growing resistant maize cultivars. The Htn1 locus confers quantitative and partial NCLB resistance by delaying the onset of lesion formation. Htn1 represents an important source of...
    Categories: Journal Articles
  • Malaria models reveal how immunity buffers climate [Population Biology]
    [Jul 2015]

    Assessing the influence of climate on the incidence of Plasmodium falciparum malaria worldwide and how it might impact local malaria dynamics is complex and extrapolation to other settings or future times is controversial. This is especially true in the light of the particularities of the short- and long-term immune responses...
    Categories: Journal Articles
  • Individual olfactory perception [Psychological and Cognitive Sciences]
    [Jul 2015]

    Each person expresses a potentially unique subset of ∼400 different olfactory receptor subtypes. Given that the receptors we express partially determine the odors we smell, it follows that each person may have a unique nose; to capture this, we devised a sensitive test of olfactory perception we termed the “olfactory...
    Categories: Journal Articles
  • Correction for Bartolome et al., Hydrological change in Southern Europe responding to increasing North Atlantic overturning during Greenland Stadial 1 [Correction]
    [Jul 2015]

    EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Correction for “Hydrological change in Southern Europe responding to increasing North Atlantic overturning during Greenland Stadial 1,” by Miguel Bartolomé, Ana Moreno, Carlos Sancho, Heather M. Stoll, Isabel Cacho, Christoph Spötl, Ánchel Belmonte, R. Lawrence Edwards, Hai Cheng, and John C. Hellstrom, which appeared in...
    Categories: Journal Articles
  • Correction for Kozakov et al., Ligand deconstruction: Why some fragment binding positions are conserved and others are not [Correction]
    [Jul 2015]

    BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Ligand deconstruction: Why some fragment binding positions are conserved and others are not,” by Dima Kozakov, David R. Hall, Sefan Jehle, Lingqi Luo, Stefan O. Ochiana, Elizabeth V. Jones, Michael Pollastri, Karen N. Allen, Adrian Whitty, and Sandor Vajda, which appeared in issue 20,...
    Categories: Journal Articles
  • Correction for Gursoy-Yuzugullu et al., Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair [Correction]
    [Jul 2015]

    CELL BIOLOGY Correction for “Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair,” by Ozge Gursoy-Yuzugullu, Marina K. Ayrapetov, and Brendan D. Price, which appeared in issue 24, June 16, 2015, of Proc Natl Acad Sci USA (112:7507–7512; first published June 1, 2015;...
    Categories: Journal Articles
  • Correction to Supporting Information for Talantova et al., A{beta} induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss [SI Correction]
    [Jul 2015]

    NEUROSCIENCE Correction to Supporting Information for “Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss,” by Maria Talantova, Sara Sanz-Blasco, Xiaofei Zhang, Peng Xia, Mohd Waseem Akhtar, Shu-ichi Okamoto, Gustavo Dziewczapolski, Tomohiro Nakamura, Gang Cao, Alexander E. Pratt, Yeon-Joo Kang, Shichun Tu, Elena Molokanova, Scott R. McKercher,...
    Categories: Journal Articles
  • In This Issue [This Week in PNAS]
    [Jul 2015]

    Biodiversity loss in grasslands Native-dominated (foreground) and exotic-dominated (background) grasslands. Image courtesy of Catherine E. Koehler (University of California Donald and Sylvia McLaughlin Natural Reserve). The consequences of global warming for species diversity are unclear, given the lack of consistent global trends toward either increased or decreased diversity. Susan Harrison...
    Categories: Journal Articles
  • QnAs with Venki Ramakrishnan [QnAs]
    [Jul 2015]

    For more than three and a half centuries, the United Kingdom’s science Academy, The Royal Society, which today occupies the stately address of 6–9 Carlton House Terrace near London’s St. James’s Park, has played a prominent role in shaping science policy in that country, offering impartial advice on scientific matters,...
    Categories: Journal Articles
  • Snapshot of insect-fungus arms race [Agricultural Sciences]
    [Jul 2015]

    The general populace associates the arms race with nations preparing for or attempting to avoid conflicts by developing and divulging their military superiority. Unfortunately, it is not just nations that engage in excessive preparation: so do cities. For example, the City of Davis, California, population 66,000 residents and 40,000 students...
    Categories: Journal Articles
  • Modeling supracellular actin ring self-assembly [Biophysics and Computational Biology]
    [Jul 2015]

    Formation of patterns during development has been a long-standing puzzle. Alan Turing proposed chemical gradients as a solution to the problem (1), and many chemical signals that pattern cells have since been found. However, only recently have roles for mechanical forces in patterning become apparent (2–6). In PNAS, Hannezo et...
    Categories: Journal Articles
  • Lose biodiversity, gain disease [Ecology]
    [Jul 2015]

    There has been a vigorous and sometimes acerbic debate about the generality of the “dilution effect”: the notion that biodiversity inhibits infectious disease, and conversely that loss of biodiversity increases disease risks to humans and livestock. In PNAS, Civitello et al. (1) report a meta-analysis of more than 200 individual...
    Categories: Journal Articles
  • How fish power suction feeding [Evolution]
    [Jul 2015]

    If you go fishing and cast your lure out across a pond, settling it skillfully by the lily pads, you may see the water drop out from under your bait with a sucking whirlpool as you engage with the most popular sport fish in the world, the largemouth bass. Almost...
    Categories: Journal Articles
  • Redesigning photosynthesis [Plant Biology]
    [Jul 2015]

    The world’s crop productivity is stagnating whereas population growth, rising affluence, and mandates for biofuels put increasing demands on agriculture. Meanwhile, demand for increasing cropland competes with equally crucial global sustainability and environmental protection needs. Addressing this looming agricultural crisis will be one of our greatest scientific challenges in the...
    Categories: Journal Articles
  • QA of IRS in visceral leishmaniasis elimination [Applied Biological Sciences]
    [Jul 2015]

    Indoor residual spraying (IRS) is used to control visceral leishmaniasis (VL) in India, but it is poorly quality assured. Quality assurance was performed in eight VL endemic districts in Bihar State, India, in 2014. Residual dichlorodiphenyltrichloroethane (DDT) was sampled from walls using Bostik tape discs, and DDT concentrations [grams of...
    Categories: Journal Articles
  • Instability driving actin pattern formation [Applied Physical Sciences]
    [Jul 2015]

    An essential question of morphogenesis is how patterns arise without preexisting positional information, as inspired by Turing. In the past few years, cytoskeletal flows in the cell cortex have been identified as a key mechanism of molecular patterning at the subcellular level. Theoretical and in vitro studies have suggested that...
    Categories: Journal Articles
  • RAG1 autoubiquitination [Biochemistry]
    [Jul 2015]

    The variable domains of Ig and T-cell receptor genes in vertebrates are assembled from gene fragments by the V(D)J recombination process. The RAG1–RAG2 recombinase (RAG1/2) initiates this recombination by cutting DNA at the borders of recombination signal sequences (RSS) and their neighboring gene segments. The RAG1 protein is also known...
    Categories: Journal Articles
  • Generating new prions in yeast [Biochemistry]
    [Jul 2015]

    Yeasts contain various protein-based genetic elements, termed prions, that result from the structural conversion of proteins into self-propagating amyloid forms. Most yeast prion proteins contain glutamine/asparagine (Q/N)-rich prion domains that drive prion activity. Here, we explore two mechanisms by which new prion domains could evolve. First, it has been proposed...
    Categories: Journal Articles
  • Mapping the binding interface of ERK and Cic [Biochemistry]
    [Jul 2015]

    Extracellular signal-regulated kinase (ERK) coordinates cellular responses to a range of stimuli by phosphorylating its numerous substrates. One of these substrates, Capicua (Cic), is a transcriptional repressor that was first identified in Drosophila and has been implicated in a number of human diseases. Here we use a chemical biology approach...
    Categories: Journal Articles
  • Mechanisms of drug discrimination by human pol {gamma} [Biochemistry]
    [Jul 2015]

    Nucleoside analog reverse transcriptase inhibitors (NRTIs) are the essential components of highly active antiretroviral (HAART) therapy targeting HIV reverse transcriptase (RT). NRTI triphosphates (NRTI-TP), the biologically active forms, act as chain terminators of viral DNA synthesis. Unfortunately, NRTIs also inhibit human mitochondrial DNA polymerase (Pol γ), causing unwanted mitochondrial toxicity....
    Categories: Journal Articles