Nature Methods
DNA profiling in India
Nature Methods 12, 995 (2015). doi:10.1038/nmeth.3653
The Indian parliament will soon discuss a bill regarding forensic DNA profiling, the terms of which will affect a vast population. It should not pass without substantial national debate and a provision for independent oversight.
The Author File: Uwe Sauer
Nature Methods 12, 997 (2015). doi:10.1038/nmeth.3628
Author: Vivien Marx
How to make cells spill their metabolic guts in high-throughput, and why work does not feel like work.
Points of Significance: Simple linear regression
Nature Methods 12, 999 (2015). doi:10.1038/nmeth.3627
Authors: Naomi Altman & Martin Krzywinski
BrowserGenome.org: web-based RNA-seq data analysis and visualization
Nature Methods 12, 1001 (2015). doi:10.1038/nmeth.3615
Authors: Jonathan L Schmid-Burgk & Veit Hornung
TransVar: a multilevel variant annotator for precision genomics
Nature Methods 12, 1002 (2015). doi:10.1038/nmeth.3622
Authors: Wanding Zhou, Tenghui Chen, Zechen Chong, Mary A Rohrdanz, James M Melott, Chris Wakefield, Jia Zeng, John N Weinstein, Funda Meric-Bernstam, Gordon B Mills & Ken Chen
Avoiding abundance bias in the functional annotation of posttranslationally modified proteins
Nature Methods 12, 1003 (2015). doi:10.1038/nmeth.3621
Authors: Christian Schölz, David Lyon, Jan C Refsgaard, Lars Juhl Jensen, Chunaram Choudhary & Brian T Weinert
Microbiology: The strain in metagenomics
Nature Methods 12, 1005 (2015). doi:10.1038/nmeth.3642
Author: Tal Nawy
Two computational tools extract strain-level information from reams of microbial sequence data.
Imaging: Super-resolution in live cells
Nature Methods 12, 1006 (2015). doi:10.1038/nmeth.3643
Author: Rita Strack
Two strategies improve structured illumination microscopy for use in live-cell super-resolution imaging.
Neuroscience: Targeting spines
Nature Methods 12, 1006 (2015). doi:10.1038/nmeth.3644
Author: Brigitta B. Gundersen
A new probe allows for optical erasure of newly activated dendritic spines.
Neuroscience: Pressuring neurons into action
Nature Methods 12, 1008 (2015). doi:10.1038/nmeth.3645
Author: Nina Vogt
An alternative to optogenetics, sonogenetics uses ultrasound to mechanically stimulate neurons.
Genomics: Single-cell DNA amplification gets even
Nature Methods 12, 1009 (2015). doi:10.1038/nmeth.3633
Bioinformatics: Improving correlated mutation analysis
Nature Methods 12, 1009 (2015). doi:10.1038/nmeth.3634
Microbiology: Growth signatures in bacterial sequence data
Nature Methods 12, 1009 (2015). doi:10.1038/nmeth.3635
Nanobiotechnology: Designing protein-DNA nanowires
Nature Methods 12, 1009 (2015). doi:10.1038/nmeth.3636
Genomics: The United Kingdom's 10K genome project
Nature Methods 12, 1010 (2015). doi:10.1038/nmeth.3637
Imaging: Optical clearing with a gentle touch
Nature Methods 12, 1010 (2015). doi:10.1038/nmeth.3638
Genomics: De novo genome assembly with nanopores
Nature Methods 12, 1010 (2015). doi:10.1038/nmeth.3639
Plant biology: Lighting up root architecture
Nature Methods 12, 1010 (2015). doi:10.1038/nmeth.3640
Systems biology: Ancient protein complexes revealed
Nature Methods 12, 1011 (2015). doi:10.1038/nmeth.3646
Author: Allison Doerr
A systematic analysis of protein-complex composition across a billion years of evolution reveals a spectrum of conservation.
Cell biology: How kinases attack signaling networks
Nature Methods 12, 1013 (2015). doi:10.1038/nmeth.3647
Author: Nicole Rusk
Two computational tools find residues that determine the specificity of any kinase and the effects of mutations in these residues on the phenotype of cancer cells.