Nature Methods

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Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.
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DNA profiling in India

Wed, 10/28/2015 - 23:00

Nature Methods 12, 995 (2015). doi:10.1038/nmeth.3653

The Indian parliament will soon discuss a bill regarding forensic DNA profiling, the terms of which will affect a vast population. It should not pass without substantial national debate and a provision for independent oversight.

The Author File: Uwe Sauer

Wed, 10/28/2015 - 23:00

Nature Methods 12, 997 (2015). doi:10.1038/nmeth.3628

Author: Vivien Marx

How to make cells spill their metabolic guts in high-throughput, and why work does not feel like work.

Points of Significance: Simple linear regression

Wed, 10/28/2015 - 23:00

Nature Methods 12, 999 (2015). doi:10.1038/nmeth.3627

Authors: Naomi Altman & Martin Krzywinski

BrowserGenome.org: web-based RNA-seq data analysis and visualization

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1001 (2015). doi:10.1038/nmeth.3615

Authors: Jonathan L Schmid-Burgk & Veit Hornung

TransVar: a multilevel variant annotator for precision genomics

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1002 (2015). doi:10.1038/nmeth.3622

Authors: Wanding Zhou, Tenghui Chen, Zechen Chong, Mary A Rohrdanz, James M Melott, Chris Wakefield, Jia Zeng, John N Weinstein, Funda Meric-Bernstam, Gordon B Mills & Ken Chen

Avoiding abundance bias in the functional annotation of posttranslationally modified proteins

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1003 (2015). doi:10.1038/nmeth.3621

Authors: Christian Schölz, David Lyon, Jan C Refsgaard, Lars Juhl Jensen, Chunaram Choudhary & Brian T Weinert

Microbiology: The strain in metagenomics

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1005 (2015). doi:10.1038/nmeth.3642

Author: Tal Nawy

Two computational tools extract strain-level information from reams of microbial sequence data.

Imaging: Super-resolution in live cells

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1006 (2015). doi:10.1038/nmeth.3643

Author: Rita Strack

Two strategies improve structured illumination microscopy for use in live-cell super-resolution imaging.

Neuroscience: Targeting spines

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1006 (2015). doi:10.1038/nmeth.3644

Author: Brigitta B. Gundersen

A new probe allows for optical erasure of newly activated dendritic spines.

Neuroscience: Pressuring neurons into action

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1008 (2015). doi:10.1038/nmeth.3645

Author: Nina Vogt

An alternative to optogenetics, sonogenetics uses ultrasound to mechanically stimulate neurons.

Genomics: Single-cell DNA amplification gets even

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1009 (2015). doi:10.1038/nmeth.3633

Bioinformatics: Improving correlated mutation analysis

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1009 (2015). doi:10.1038/nmeth.3634

Microbiology: Growth signatures in bacterial sequence data

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1009 (2015). doi:10.1038/nmeth.3635

Nanobiotechnology: Designing protein-DNA nanowires

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1009 (2015). doi:10.1038/nmeth.3636

Genomics: The United Kingdom's 10K genome project

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1010 (2015). doi:10.1038/nmeth.3637

Imaging: Optical clearing with a gentle touch

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1010 (2015). doi:10.1038/nmeth.3638

Genomics: De novo genome assembly with nanopores

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1010 (2015). doi:10.1038/nmeth.3639

Plant biology: Lighting up root architecture

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1010 (2015). doi:10.1038/nmeth.3640

Systems biology: Ancient protein complexes revealed

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1011 (2015). doi:10.1038/nmeth.3646

Author: Allison Doerr

A systematic analysis of protein-complex composition across a billion years of evolution reveals a spectrum of conservation.

Cell biology: How kinases attack signaling networks

Wed, 10/28/2015 - 23:00

Nature Methods 12, 1013 (2015). doi:10.1038/nmeth.3647

Author: Nicole Rusk

Two computational tools find residues that determine the specificity of any kinase and the effects of mutations in these residues on the phenotype of cancer cells.