A fuller understanding of how a virus establishes infection should help in developing approaches that minimize the associated pathology. On page 563 in this issue, Sewald et al. (1) succeed in visualizing interactions between retroviruses and cells within the immune tissues of live mice. This is exciting and notable for two reasons. It provides visual insights into the earliest steps leading to systemic infection in a living animal. Additionally, it demonstrates that multiple modes of infection can be used by a virus during dissemination. The observations described begin to reveal the complex steps that a virus must take to establish systemic infection. Author: Thomas J. Hope

Until the late 1980s, textbooks portrayed economics as a nonexperimental science because it was thought that “Economists…cannot perform the controlled experiments of chemists or biologists.…Like astronomers or meteorologists, they generally must be content largely to observe” (1). Since then, economics has experienced an experimental revolution (2–6). However, there has been a debate on the extent to which insights from economic lab experiments can be generalized to field settings (7–11). On page 545 of this issue, Herbst and Mas (12) show that the results of a class of lab experiments can be generalized to the field because they provide quantitatively precise descriptions of productivity spillovers between workers. Authors: Gary Charness, Ernst Fehr

Pharmaceutical small-molecule drugs are the first “pillar” of modern medicinal therapeutics, with recombinant protein biologics claiming the second pillar. If the emergent third pillar of medicine is cell-based therapeutics, cellular immunotherapy of cancer stands as the pillar's current poster child (1). This approach includes adoptive T cell therapy, which has seen major advances recently. Underlying some of this progress are developments in synthetic tumor recognition receptors. Although it's early days for applied synthetic immunobiology, increasing momentum in this field may soon lead to the application of engineered T cells to a broader spectrum of cancers as well as to infectious and autoimmune diseases. Author: Michael C. Jensen

Humans, Old World monkeys, gibbons, and the great apes of Africa and Asia are the only survivors of a highly diverse evolutionary radiation that began at least 28 million years ago (1, 2). The fossil record of human evolution after we diverged from apes is rich, but much less is known about the evolutionary history of modern apes. Not only is the fossil record incomplete but also the morphology of primitive apes from the Miocene (25 to 5 million years ago) seldom conforms to expectations based on living species. The ancestors of gibbons are particularly elusive. On page 528 of this issue, Alba et al. describe a Miocene fossil from Catalonia, Spain, that may bridge the gap between earlier small-bodied African apelike primates and living gibbons (3). Authors: Brenda R. Benefit, Monte L. McCrossin

Eric Davidson made major contributions to elucidating the mechanisms and logical structure of developmental gene regulatory networks. The Norman Chandler Professor of Cell Biology at the California Institute of Technology, Eric died of a heart attack on 1 September 2015 in Pasadena, California. Eric's death came just a few months after the publication of his latest book, Genomic Control Process: Development and Evolution, coauthored with his colleague Isabelle Peter. In this book, Eric and Isabelle continued to push forward his career-long project of applying rigorous experimental, modeling, and conceptual studies to understanding mechanisms responsible for the operation of gene regulatory networks, as well as how they had evolved through time. Author: Douglas H. Erwin

Authors: Miha Krofel, Adrian Treves, William J. Ripple, Guillaume Chapron, José V. López-Bao

Authors: Mathilde Bonnefond, Livio Riboli-Sasco, Guillaume Sescousse

Authors: Raoni Rajão, Britaldo Soares-Filho

Li et al. (Reports, 30 January, p. 555) reported on a crystal structure for a translocator protein (TSPO) from Rhodobacter sphaeroides in which some of the electron density is modeled as a porphyrin. The analysis of the x-ray data discussed here suggests that this assignment is incorrect. Author: Jimin Wang

Wang comments that the diffraction data for the structure of the A139T mutant of translocator protein TSPO from Rhodobacter sphaeroides should be used to 1.65 instead of 1.8 angstroms and that the density interpreted as porphyrin and monoolein is better fitted as polyethylene glycol. Although different practices of data processing exist, in this case they do not substantially influence the final map. Additional data are presented supporting the fit of a porphyrin and monooleins. Authors: Fei Li, Jian Liu, Yi Zheng, R. Michael Garavito, Shelagh Ferguson-Miller

Climate change is affecting the region's estuaries, politics, and what it means to go home Authors: Kathy Wren, Gavin Stern

The inaugural AAAS Marion Milligan Mason awards recognized four outstanding chemists and mentors Authors: Kathy Wren, Andrea Korte

Author: Sacha Vignieri

Author: Marc S. Lavine

Author: Brent Grocholski

Author: Jelena Stajic

Author: Peter Stern

Author: Kristen L. Mueller

Author: Orla M. Smith