Journal Articles

  • Association between mRNA expression and phenotype [Genetics]
    [Apr 2015]

    High-throughput gene expression profiling has revealed substantial leaky and extraneous transcription of eukaryotic genes, challenging the perceptions that transcription is strictly regulated and that changes in transcription have phenotypic consequences. To assess the functional implications of mRNA transcription directly, we analyzed mRNA expression data derived from microarrays, RNA-sequencing, and in...
    Categories: Journal Articles
  • TOP3{alpha} and RECQ4 limit meiotic crossovers [Genetics]
    [Apr 2015]

    Meiotic crossovers (COs) have two important roles, shuffling genetic information and ensuring proper chromosome segregation. Despite their importance and a large excess of precursors (i.e., DNA double-strand breaks, DSBs), the number of COs is tightly regulated, typically one to three per chromosome pair. The mechanisms ensuring that most DSBs are...
    Categories: Journal Articles
  • Immune activation in human Ebola virus infection [Immunology and Inflammation]
    [Apr 2015]

    Four Ebola patients received care at Emory University Hospital, presenting a unique opportunity to examine the cellular immune responses during acute Ebola virus infection. We found striking activation of both B and T cells in all four patients. Plasmablast frequencies were 10–50% of B cells, compared with less than 1%...
    Categories: Journal Articles
  • Inflammatory, bladder-cancer-promoting cells [Immunology and Inflammation]
    [Apr 2015]

    Nonresolving chronic inflammation at the neoplastic site is consistently associated with promoting tumor progression and poor patient outcomes. However, many aspects behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain undefined. Using bladder cancer (BC) as a model, we found that CD14-high cancer cells express higher levels of numerous...
    Categories: Journal Articles
  • G{alpha}i1 and G{alpha}i3 regulate macrophage polarization [Immunology and Inflammation]
    [Apr 2015]

    Heterotrimeric G proteins have been implicated in Toll-like receptor 4 (TLR4) signaling in macrophages and endothelial cells. However, whether guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Gαi1/3) are required for LPS responses remains unclear, and if so, the underlying mechanisms need to be studied. In this study, we demonstrated...
    Categories: Journal Articles
  • Giant temperature response of nanobionic materials [Plant Biology]
    [Apr 2015]

    Conventional approaches to create biomaterials rely on reverse engineering of biological structures, on biomimicking, and on bioinspiration. Plant nanobionics is a recent approach to engineer new materials combining plant organelles with synthetic nanoparticles to enhance, for example, photosynthesis. Biological structures often outperform man-made materials. For example, higher plants sense temperature...
    Categories: Journal Articles
  • Family environment and cognitive ability [Psychological and Cognitive Sciences]
    [Apr 2015]

    Cognitive ability strongly aggregates in families, and prior twin and adoption studies have suggested that this is the result of both genetic and environmental factors. In this study, we used a powerful design—home-reared and adopted-away cosibling controls—to investigate the role of the rearing environment in cognitive ability. We identified, from...
    Categories: Journal Articles
  • Water conservation and food security in China [Sustainability Science]
    [Apr 2015]

    China’s economic growth is expected to continue into the next decades, accompanied by sustained urbanization and industrialization. The associated increase in demand for land, water resources, and rich foods will deepen the challenge of sustainably feeding the population and balancing agricultural and environmental policies. We combine a hydrologic model with...
    Categories: Journal Articles
  • Capturing cancer's complexity [News Feature]
    [Apr 2015]

    Some researchers believe that a tumor's heterogeneity provides crucial clues about how cancers respond to treatment. Looking down from an airplane window, it’s hard to appreciate the diversity of plants that thrive in a lush forest thousands of feet below. The shade of green might hint at a dominant species,...
    Categories: Journal Articles
  • Modular Degradable Hydrogels Based on Thiol-Reactive Oxanorbornadiene Linkers
    [Apr 2015]

    Journal of the American Chemical SocietyDOI: 10.1021/jacs.5b02708
    Categories: Journal Articles
  • Spotlights on Recent JACS Publications
    [Apr 2015]

    Journal of the American Chemical SocietyDOI: 10.1021/jacs.5b03817
    Categories: Journal Articles
  • Close the deal
    [Apr 2015]

    Nature -

    Close the deal

    Nature 520, 7547 (2015). doi:10.1038/520263a

    Science-based evidence and enlightened diplomacy have brought within reach a historic opportunity for nuclear détente with Iran. It must be seized.

    Categories: Journal Articles
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